Association-of-Hypertension-and-Antihypertensive-Treatment-with-Memory-Decline

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Association-of-Hypertension-and-Antihypertensive-Treatment-with-Memory-Decline

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This project analyzes longitudinal data from HRS, ELSA, MHAS, and CHARLS to investigate hypertension, antihypertensive treatment status, and 6-8-year memory decline in adults ≥50 across the US, England, Mexico, and China. Findings underscore hypertension as a modifiable target for ADRD mitigation, advocating tailored public health strategies.

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# Association of Hypertension and Antihypertensive Treatment with Memory Function and Decline among Middle-Aged and Older Adults across Four Countries, 2010 to 2019
# Overview
This project leverages data from four longitudinal studies (HRS, ELSA, MHAS, CHARLS) to explore the association between hypertension, its treatment status, and long - term memory decline over 6 - 8 years among adults aged 50+ in the US, England, Mexico, and China. It examines how hypertension (defined by BP levels or antihypertensive use) and antihypertensive treatment impact memory function (assessed via word recall scores, standardized as Z - scores). Results reveal cross - country variations in the link between hypertension, treatment, and memory decline, highlighting the need for tailored public health strategies to mitigate ADRD burden by targeting these modifiable factors.

# Requirement
R version 4.2 or higher

# Scripts descriptions
- The file "HRS" includes all analysis code developed for the HRS cohort studies.
- The file "ELSA" includes all analysis code developed for the ELSA cohort studies.
- The file "MHAS" includes all analysis code developed for the MHAS cohort studies.
- The file "CHARLS" includes all analysis code developed for the CHARLS cohort studies.
- The file "Pooled analysis" includes all analysis code conducted for cross-country comparison.

Association-of-Hypertension-and-Antihypertensive-Treatment-with-Memory-Decline

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